DOTA-PEG3-TCO-4-en / axial isomer
DOTA-PEG3-TCO-4en can be used in radiopharmacy, targeted cancer therapy, and bioorthogonal chemistry, particularly in areas such as diagnostic imaging and personalized medicine.
TCO-4-en serves as a click chemistry handle that readily reacts with tetrazine groups on a target molecule. DOTA can chelate divalent and trivalent cations, e.g. Gallium
| Catalogue | SC-3000 |
|---|---|
| Formula | C33H58N6O12 |
| CAS | -- |
| MW | 730,86 |
| Appearance | white powder |
| Purity | > 97% (HPLC-UV λ=254nm) |
| Solubility | Soluble in water |
| Size | 10mg / 50mg |
| Storage | Keep cool and dry. Protect from light and moisture. Store at - 20°C on arrival. |
Possible applications DOTA-PEG3-TCO-4-en:
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Radiopharmacy (Diagnostic Imaging): This substance could be used for PET imaging, where the DOTA molecule is conjugated with a radioactive isotope (e.g., Gallium-68). This compound could then be used to locate tumors or other diseased tissues in the body.
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Targeted Cancer Therapy: By utilizing TCO and bioorthogonal chemistry, DOTA-PEG3-TCO-4en could be employed in the development of targeted therapies. The substance could specifically bind to cancer cells and deliver a therapeutic agent (e.g., a radioactive isotope or a cytostatic drug) directly to them.
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Bioorthogonal Chemistry: This compound could be used in the research and development of bioorthogonal markers and therapeutic systems, where DOTA-PEG3-TCO-4en reacts specifically with other bioorthogonal systems (e.g., tetrazine) to deliver markers or therapeutic molecules to specific target structures.