Gibberellic Acid-AM-Ester (GA3-AM)
GA3-AM is a cell permeable analog of the plant hormone gibberellic acid that acts as a chemical dimerizer and a chemical inducer of proximity (CIP) similar to rapamycin
| Catalogue | SC-4000 |
|---|---|
| Formula | C22H26O8 |
| CAS | 1373154-68-7 |
| MW | 418,44 |
| Appearance | white solid |
| Purity | > 95% (HPLC-UV λ=210nm) |
| Solubility | Soluble ACN, Methanol, DMSO, DMF |
| Size | 100mg |
| Storage | Keep cool and dry. Protect from light and moisture. Store at - 20°C on arrival. |
Gibberellic acid (GA3) is a plant hormone that can be used as a chemical inducer of proximity (CIP) similar to rapamycin.
The acetoxymethyl ester modification GA3-AM allows to easily penetrate cell membranes, which is particularly useful for in vivo studies where efficient delivery of GA into cells is required.
Once inside the cell, cellular esterases hydrolyze GA3-AM, releasing the active GA3. This process ensures that the GA3 is only activated inside the cell, reducing potential side effects outside the target area.
Light-induced protein proximity by activation of gibberellic acid derivatives in living cells//
Methods in Enzymology, Volume 638, 2020
doi.org/10.1016/bs.mie.2020.02.022
Light-Induced Protein Dimerization by One- and Two-Photon Activation of Gibberellic Acid Derivatives in Living Cells
Angew. Chem. Int. Ed. 2015, 54, 2825 –2829
DOI: 10.1002/anie.201409196
Characterizing gibberellin flow in planta using
photocaged gibberellins†
Chem. Sci., 2019, 10, 1500
DOI: 10.1039/c8sc04528c