Chemical Dimerizer rCD1

The first rapidly reversible chemical dimerization system. Contains also a vial of FK506 !
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Catalogue SC-7000
Formula C48H58N8O
CAS 1616757-84-6
MW 891.04
Appearance powder
Purity 90% (HPLC-UV)
Solubility e.g. imaging buffer (1µM) / or prepare a stock solution: 2-4 mM in dry DMSO
Size 100 µg / 500 µg
Storage Keep cool and dry.

The first rapidly reversible chemical dimerization system – rCD1 - , which permits to determine kinetics of lipid metabolizing enzymes in living cells, is now available at SiChem . This new system was applied to induce and stop the activity of phosphatidyl 3-kinase (PI3K) [Feng, S., Laketa, V., Stein, F., Rutkowska, A., MacNamara, A., Depner, S., Klingmuller, U., Saez-Rodriguez, J. & Schultz, C.
Angew Chem Int Ed Engl. 2014, 53: 6720 –6723] doi: 10.1002/anie.201402294

Recruitment of a splicing factor to the nuclear lamina for its inactivation

bioRxiv 2022 preprint //
A F420-dependent single domain chemogenetic tool for protein de-dimerization