Chemical Dimerizer rCD1
| Catalogue | SC-7000 |
|---|---|
| Formula | C48H58N8O |
| CAS | 1616757-84-6 |
| MW | 891.04 |
| Appearance | powder |
| Purity | 90% (HPLC-UV) |
| Solubility | e.g. imaging buffer (1µM) / or prepare a stock solution: 2-4 mM in dry DMSO |
| Size | 100 µg / 500 µg |
| Storage | Keep cool and dry. |
The first rapidly reversible chemical dimerization system – rCD1 - , which permits to determine kinetics of lipid metabolizing enzymes in living cells, is now available at SiChem . This new system was applied to induce and stop the activity of phosphatidyl 3-kinase (PI3K) [Feng, S., Laketa, V., Stein, F., Rutkowska, A., MacNamara, A., Depner, S., Klingmuller, U., Saez-Rodriguez, J. & Schultz, C.
Angew Chem Int Ed Engl. 2014, 53: 6720 –6723] doi: 10.1002/anie.201402294
COMMUNICATIONS BIOLOGY | (2022) 5:736 | doi.org/10.1038/s42003-022-03689-y
Recruitment of a splicing factor to the nuclear lamina for its inactivation
bioRxiv 2022 preprint // doi.org/10.1101/2022.11.07.515376
A F420-dependent single domain chemogenetic tool for protein de-dimerization