Lipidated FRET-based reporter system that detects Neutrophil elastase (NE) activity.

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250,00 €
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Katalognummer SC-0201
Formel C142H210N24O39S
CAS --
MW 2909,43
Aussehen 1mM stock solution in DMSO
Reinheit > 90% (HPLC-UV λ=443 nm)
Löslichkeit Soluble in DMSO
Größe 10 µL / 50 µL
Aufbewahrung Keep cool and dry. Protect from light and moisture. Store at -20°C.

NEmo is a FRET-based reporter system that detects Neutrophil elastase (NE) activity on cell surfaces or in solution. NE is a novel biomarker in patients with cystic fibrosis (CF) and potentially other chronic neutrophilic lung diseases.

Here you will find supporting information for NEmo application:

JoVE (DOI: 10.3791/62193-v)


Selected References:

Chung, J.; et al.: Increased Inflammatory Markers Detected in Nasal Lavage Correlate with Paranasal Sinus Abnormalities at MRI in Adolescent Patients with Cystic Fibrosis. Antioxidants 2021, 10,1412.

Margaroli et al.: Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophils, 2021, Cell Reports Medicine 2, 100239