Lu-p-SCN-Bn-DOTA

Lu-p-SCN-Bn-DOTA (CAS 2261022-56-2) 

Lu-p-SCN-Bn-DOTA is a bifunctional chelating agent in which the para-isothiocyanatobenzyl-DOTA ligand is pre-complexed with Lutetium (III). This conjugate combines two critical functionalities that make it highly suitable for advanced radiopharmaceutical research and development:

• Isothiocyanate (-SCN) reactive group
  Enables efficient and stable covalent coupling to amino groups of biomolecules (e.g., lysine residues in antibodies, peptides, or other ligands). The resulting thiourea bond provides strong and durable attachment, ensuring conjugate integrity during subsequent processing and in vivo applications.

• DOTA macrocyclic chelator
  Offers exceptionally stable coordination of Lutetium (III), minimizing the risk of decomplexation under physiological conditions. The DOTA scaffold is well established as the gold standard for radiometal chelation in nuclear medicine.

Applications

Lu-p-SCN-Bn-DOTA is primarily utilized in the development of targeted radiopharmaceuticals:

• Therapeutic – Suitable for Lutetium-177 radiolabeling, enabling the design of antibody-drug conjugates or peptide conjugates for targeted radionuclide therapy (e.g., neuroendocrine tumors, prostate cancer).

• Theranostic – Combines therapeutic beta-emission from Lu-177 with accompanying gamma photons for SPECT imaging, supporting dosimetry and therapy monitoring.

Key Benefits

• Pre-loaded with Lutetium for streamlined workflows

• High chelation stability and in vivo robustness

• Versatile bioconjugation via isothiocyanate group

• Ideal for preclinical and translational radiopharmaceutical research