DOTA-PEG4-NH2 / xTFA salt
NH₂-PEG₄-DOTA (CAS 2090232-34-9) is a bifunctional DOTA chelator with a PEG₄ linker and terminal amine group. It enables efficient bioconjugation to peptides, antibodies, or other biomolecules and provides highly stable radiometal complexes, making it ideal for radiopharmaceutical R&D
Powered by Bioz| Katalognummer | SC-3015 |
|---|---|
| Formel | C26H50N6O11 |
| CAS | 2090232-34-9 |
| MW | 622,71 |
| Aussehen | off white solid |
| Reinheit | > 95% (HPLC-UV @220nm) |
| Löslichkeit | Soluble in water, DMF |
| Größe | 1g |
| Aufbewahrung | Keep cool and dry. Protect from light and moisture. Store at - 20°C on arrival. |
NH₂-PEG₄-DOTA (CAS 2090232-34-9) is a bifunctional chelator combining a DOTA macrocyclic core with a PEG₄ linker and a reactive terminal amine group. The DOTA scaffold forms highly stable complexes with both radioactive isotopes (e.g., Lu-177, Ga-68, Y-90, Cu-64) and their corresponding stable isotopes (Lu-175, Ga-69/71, Y-89, Cu-63/65).
This versatility makes NH₂-PEG₄-DOTA suitable for preclinical method development and quality control using non-radioactive metals, before progressing to radiolabeled conjugates for therapeutic or imaging applications. The PEG₄ spacer enhances solubility and reduces steric hindrance, while the amine group allows straightforward bioconjugation to peptides, antibodies, or other biomolecules.
Applications:
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Chelation of stable (Lu-175, Ga-69/71, Y-89, Cu-63/65) and radioactive isotopes (Lu-177, Ga-68, Y-90, Cu-64)
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Antibody and peptide labeling in radiopharmaceutical R&D
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Preclinical method development without handling radioactivity
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Theranostic probe and radioligand conjugate development