Ins(123456)P6
myo-Inositol 1,2,3,4,5,6-hexakisphosphate (InsP6, IP6, phytic acid), sodium salt.
| Katalognummer | 6-0-123456-Na |
|---|---|
| Formel | C6H18O24P6 * xNa*yH2O |
| CAS | 83-86-3 / 14306-25-3 (sodium salt) |
| MW | 660.04 |
| Aussehen | Lyophilized white powder |
| Reinheit | > 95 % (31P-NMR) |
| Löslichkeit | in water |
| Größe | 5 g / 25 g |
| Aufbewahrung | Keep cool and dry. Protect from light and moisture |
myo-Inositol 1,2,3,4,5,6-hexakisphosphate (InsP6, IP6), also known as phytic acid, is the fully phosphorylated derivative of myo-inositol. It is a naturally occurring inositol phosphate with diverse functions in cellular signaling and protein regulation.
InsP6 interacts with numerous cellular proteins and can contribute to the stabilization and regulation of protein complexes. It also serves as a precursor for inositol pyrophosphates and has been extensively investigated in processes including phosphate homeostasis, cellular metabolism and viral assembly.
A prominent example is HIV-1, where InsP6 acts as an assembly cofactor that promotes formation and stabilization of both immature and mature viral capsid structures. This product is supplied as the sodium salt.
References:
Dick R.A. et al., Nature 2018, 560, 509–512. DOI: 10.1038/s41586-018-0396-4
Desfougères Y. et al., Proceedings of the National Academy of Sciences of the United States of America 2019, 116, 24551–24561. DOI: 10.1073/pnas.1911431116
Renner N. et al., Nature Structural & Molecular Biology 2023, 30, 370–382. DOI: 10.1038/s41594-022-00887-4
Develin A.M. et al., Biochemistry 2024, 63, 1097–1106. DOI: 10.1021/acs.biochem.4c00117
Rameh L.E. et al., Journal of Biological Chemistry 2025, 301, 108095. DOI: 10.1016/j.jbc.2024.108095
Saverino A. et al., Biomolecules 2025, 15, 1652. DOI: 10.3390/biom15121652
