2-O-Butyryl-1-O-octyl-myo-inositol-3,4,5,6-tetrakisphosphate octakis(propionoxymethyl) ester
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300,00 €
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Katalognummer INO-4995
Formel C50H86O35P4
CAS 868171-91-9
MW 1371.10
Aussehen A clear syrup
Reinheit > 98%
Löslichkeit Toluene and DMSO / Chloroform
Größe 1 mg / 10 mg
Aufbewahrung Keep cool and dry. Protect from light and moisture. Store at -20°C.
2-O-Butyryl-1-O-octyl-myo-inositol-3,4,5,6-tetrakisphosphate octakis(propionoxymethyl) ester INO-4995 (1-O-octyl-2-O-butyryl-D-myo-inositol 3,4,5,6-tetrakisphosphate octakis (propionoxymethyl) ester) is an ion channel modulator that is slowly metabolized in cells. Studies have shown that it inhibits ENaC activity while promoting expression of the calcium-activated chloride channel, TMEM16a, in membranes. Thus it has potential therapeutic activity in the treatment of cystic fibrosis where it normalized nasal potential difference (NPD) in a murine CF knock-out model and promoted fluid secretion in human CF airway epithelia [Tian, Y.; Schreiber, R,; Wanitchakool, P.; Kongsuphol, P.; Sousa, M.; Uliyakina, I.; Palma, M.; Faria; D.; Traynor-Kaplan, A. E.; Fragata, J. I.: British Journal of Pharmacology 2013, 168(1), 253-265 // [Traynor-Kaplan, A.E.; Moody, M.; Nur, M.; Gabriel, S.; Majerus, P. W.; Drumm, M. L.; Langton- Webster, B.: Am J Respir Cell Mol Biol. 2010 Jan; 42(1): 105–112]
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